 |
 |
 |
 |
| Acetyl-CoA |
+ |
Acetoacetyl-CoA |
|
|
H2O
CoASH |
 |
Hydroxymethyl glutaryl CoA synthase |
|
|
|
 |
|
|
3-Hydroxy-3-methyl-glutaryl CoA |
|
|
|
2 NADPH + H+
2 NADP+, CoA-S-H |
 |
Hydroxymethyl glutaryl CoA reductase |
|
|
|
 |
|
|
Mevalonate |
|
|
|
ATP
ADP |
 |
Mg++
Mevalonate kinase |
|
|
|
 |
|
|
Mevalonate-5-phosphate |
|
|
|
ATP
ADP |
|
Mg++
Phosphomevalonate kinase |
|
|
|
 |
|
|
Mevalonate-5-pyrophosphate |
|
|
|
ATP
ADP, Pi, CO2 |
|
Diphosphomevalonate decarboxylase |
|
|
|
 |
|
|
D3-Isopentenyl pyrophosphate |
|
|
|
|
 |
 |
Mg++
Isopentenyldiphosphate isomerase |
|
|
|
 |
|
|
Dimethylallyl pyrophosphate |
|
|
|
D3-Isopentenyl pyrophosphate
PPi |
|
Dimethylallyl-trans-transferase |
|
|
|
 |
|
|
Geranyl pyrophosphate |
|
|
|
D3-Isopentenyl pyrophosphate
PPi |
|
Geranyl-trans-transferase |
|
|
|
 |
|
|
Farnesyl pyrophosphate |
|
|
|
Farnesyl pyrophosphate
Farnesyl-PP farnesyl transferase |
 |
NADPH, H+
NADP+ |
|
|
|
 |
|
|
Squalene |
|
|
|
| Squalene Monooxygenase |
O2
H2O |
 |
NADPH, H+
NADP+ |
|
|
|
 |
|
|
(S)-Squalene-2,3-epoxide |
|
|
|
|
 |
Lanesterol synthase |
|
|
|
 |
|
|
Lanosterol |
|
|