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BAC to BAC

Sequencing

Whole Genome Shotgun Sequencing

These pieces are fingerprinted to give each piece a unique identification tag that determines the order of the fragments

Fingerprinting involves cutting each BAC fragment with a single enzyme and finding common sequence landmarks in overlapping fragments that determine the location of each BAC along the chromosome

Then overlapping BACs with markers every 100,000 bp form a map of each chromosome

This step not needed in shotgun sequencing

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