Main Publications
Laboratory of Pulmonary Immunology and Mechanics
Laboratory of Experimental Oral Pathology
Immunoregulation of infectious diseases
Translational Psychoneuroimmunology Group
SIGNALING IN INFLAMMATION
Vago, J. P. ; Nogueira, C. R. C. ; Tavares, L. P. ; Soriani, F. M. ; Lopes, F. ; RUSSO, R. C. ; Pinho, V. ; Teixeira, M. M. ; Sousa, L. P. . Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis. Journal of Leukocyte Biology, v. 92, p. 1, 2012. J.
Sousa, L. P. ; Lopes, F. ; Silva, D. M. ; Tavares, L. P. ; Vieira, A. T. ; Rezende, B. M. ; Carmo, A. F. ; RUSSO, R. C. ; GARCIA, C. C. ; Bonjardim, C. A. ; Alessandri, A. L. ; Rossi, A. G. ; Pinho, V. ; Teixeira, M. M. . PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF- B-independent manner. Journal of Leukocyte Biology, p. 1-10, 2010.
Garcia, Cristiana C. ; Russo, Remo C. ; Guabiraba, Rodrigo ; Fagundes, Caio T. ; Polidoro, Rafael B. ; Tavares, Luciana P. ; Salgado, Ana Paula C. ; Cassali, Geovanni D. ; Sousa, Lirlândia P. ; Machado, Alexandre V. ; Teixeira, Mauro M. . Platelet-Activating Factor Receptor Plays a Role in Lung Injury and Death Caused by Influenza A in Mice. PLoS Pathogens, v. 6, p. e1001171, 2010.
Sousa, Lirlândia P. ; Carmo, Aline F. ; Rezende, Bárbara M. ; Lopes, Fernando ; Silva, Douglas M. ; Alessandri, Ana L. ; Bonjardim, Cláudio A. ; Rossi, Adriano G. ; Teixeira, Mauro M. ; PINHO, Vanessa . Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-?B. Biochemical Pharmacology, v. 78, p. 396-405, 2009.
Sousa LP, Silva BM, Brasil BS, Nogueira SV, Ferreira PC, Kroon EG, Kato K, Bonjardim CA. Plasminogen/plasmin regulates alpha-enolase expression through the MEK/ERK pathway. Biochem Biophys Res Commun. 2005 Dec 2;337(4):1065-71.
Sousa LP, Brasil BS, Silva Bde M, Nogueira SV, Andrade AA, Ferreira PC, Teixeira SM, Gollob KJ, Kroon EG, Kato K, Bonjardim CA.Characterization of alpha-enolase as an interferon-alpha 2 alpha 1 regulated gene.Front Biosci. 2005 Sep 1;10:2534-47.
De Sousa LP, Brasil BS, Silva BM, Freitas MH, Nogueira SV, Ferreira PC, Kroon EG, Bonjardim CA.Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway.Biochem Biophys Res Commun. 2005 Apr 1;329(1):237-45.
FUNCTIONAL GENETICS LABS
Marques, Pedro E.; Amaral, Sylvia S.; Pires, Daniele A.; Nogueira, Laura L.; Soriani, Frederico M.; Lima, Braulio H.F.; Lopes, Gabriel A.O. ; Russo, Remo C.; Ávila, Thiago V.; Melgaço, Juliana G.; Oliveira, André G.; Pinto, Marcelo A.; Lima, Cristiano X.; De Paula, Ana Maria; Cara, Denise C.; Leite, Maria F.; Teixeira, Mauro M.; Meneses, Gustavo Batista. Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. Hepatology, v. 56, p. 1971-1982, 2012.
Amaral, Flávio A.; Costa, Vivian V.; Tavares, Livia D.; Sachs, Daniela; Coelho, Fernanda M.; Fagundes, Caio T.; Soriani, Frederico M.; Silveira, Tatiana N.; Cunha, Larissa D.; Zamboni, Dario S.; Quesniaux, Valerie; Peres, Raphael S.; Cunha, Thiago M.; Cunha, Fernando Q.; Ryffel, Bernhard; Souza, Daniele G.; Teixeira, Mauro M. NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout. Arthritis and Rheumatism, v. 64, p. 474-484, 2012.
Lacerda-Queiroz, Norinne; Rodrigues, David H. ; Vilela, Márcia C. ; Rachid, Milene A. ; Soriani, Frederico M. ; Sousa, Lirlândia P.; Campos, Roberta D.L. ; Quesniaux, Valerie F.J.;Teixeira, Mauro M.; Teixeira, Antonio L.. Platelet-Activating Factor Receptor Is Essential for the Development of Experimental Cerebral Malaria. The American Journal of Pathology, v. 180, p. 246-255, 2012.
Vago, J. P.; Nogueira, C. R. C.; Tavares, L. P.; Soriani, F. M.; Lopes, F.; Russo, R. C.; Pinho, V.; Teixeira, M. M.; Sousa, L. P. Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis. Journal of Leukocyte Biology, v. 92, p. 1-10, 2012.
Martins, V. P. ; Dinamarco, T. M. ; Soriani, F. M. ; Tudella, V. G. ; Oliveira, S. C. ; Goldman, G. H. ; Curti, C. ; Uyemura, S. A. . Involvement of an Alternative Oxidase in Oxidative Stress and Mycelium-to-Yeast Differentiation in Paracoccidioides brasiliensis. Eukaryotic Cell, v. 10, p. 237-248, 2011.
Soriani, Fm ; Malavazi, I. ; Savoldi, M. ; Espeso, E. ; Dinamarco, Tm ; Bernardes, Las ; Ferreira, M. E. Da S. ; Goldman, M. H. S. ; Goldman, G. H. . Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA. BMC Microbiology, v. 10, p. 1, 2010.
Han, Kap-Hoon ; Chun, Yoon-Hee ; de Castro Pimentel Figueiredo, Bárbara ; Soriani, Frederico Marianetti ; Savoldi, Marcela ; Almeida, Agostinho ; Rodrigues, Fernando ; Cairns, Charlie Timothy ; Bignell, Elaine ; Tobal, Jaqueline Moisés ; Goldman, Maria Helena S. ; Kim, Jong-Hwan ; Bahn, Yong-Sun ; Goldman, Gustavo Henrique ; da Silva Ferreira, Márcia Eliana . The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans. Molecular Microbiology, v. 75, p. 1372-1388, 2010.
Teixeira, Mauro M. ; Vilela, Marcia C. ; Soriani, Frederico M. ; Rodrigues, David H. ; Teixeira, Antonio L. . Using intravital microscopy to study the role of chemokines during infection and inflammation in the central nervous system. Journal of Neuroimmunology, v. 224, p. 62-65, 2010.
Dinamarco, Taísa Magnani ; Figueiredo Pimentel, Bárbara de Castro ; Savoldi, Marcela; Malavazi, Iran ; Soriani, Frederico Marianetti ; Uyemura, Sérgio Akira ; Ludovico, Paula; Goldman, Maria Helena S. ; Goldman, Gustavo Henrique . The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance. Fungal Genetics and Biology, v. 47, p. 1055-1069, 2010.
Garcia, C.C.; Guabiraba, R.; Soriani, F.M.; Teixeira, Mauro M. The development of anti-inflammatory drugs for infectious diseases. Discovery Medicine, v. 10, p. 479-488, 2010.
Martins, V. P.; Dinamarco, T. M.; Soriani, F. M.; Tudella, V. G.; Oliveira, S. C.; Goldman, G. H.; Curti, C.; Uyemura, S. A. The involvement of an alternative oxidase in oxidative stress and mycelia-to-yeast differentiation in Paracoccidioides brasiliensis. Eukaryotic Cell, v. 10, p. 237-248, 2010.
LABORATORY OF PULMONARY IMMUNOLOGY AND MECHANICS
Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor. Bertini R, Barcelos LS, Beccari AR, Cavalieri B, Moriconi A, Bizzarri C, Di Benedetto P, Di Giacinto C, Gloaguen I, Galliera E, Corsi MM, Russo RC, Andrade SP, Cesta MC, Nano G, Aramini A, Cutrin JC, Locati M, Allegretti M, Teixeira MM. Br J Pharmacol. 2012 Jan;165(2):436-54. doi: 10.1111/j.1476-5381.2011.01566.x.
Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffê E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM. J Leukoc Biol. 2011 Feb;89(2):269-82. Epub 2010 Nov 2.
Therapeutic effects of evasin-1, a chemokine binding protein, in bleomycin-induced pulmonary fibrosis. Russo RC, Alessandri AL, Garcia CC, Cordeiro BF, Pinho V, Cassali GD, Proudfoot AE, Teixeira MM. Am J Respir Cell Mol Biol. 2011 Jul;45(1):72-80. Epub 2010 Sep 10.
Anti-inflammatory drug development: Broad or specific chemokine receptor antagonists? Russo RC, Garcia CC, Teixeira MM. Curr Opin Drug Discov Devel. 2010 Jul;13(4):414-27. Review.
Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. Garcia CC, Russo RC, Guabiraba R, Fagundes CT, Polidoro RB, Tavares LP, Salgado AP, Cassali GD, Sousa LP, Machado AV, Teixeira MM. PLoS Pathog. 2010 Nov 4;6(11):e1001171.
Regulation of leukocyte recruitment by the long pentraxin PTX3. Deban L, Russo RC, Sironi M, Moalli F, Scanziani M, Zambelli V, Cuccovillo I, Bastone A, Gobbi M, Valentino S, Doni A, Garlanda C, Danese S, Salvatori G, Sassano M, Evangelista V, Rossi B, Zenaro E, Constantin G, Laudanna C, Bottazzi B, Mantovani A. Nat Immunol. 2010 Apr;11(4):328-34. Epub 2010 Mar 7.
Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis. Russo RC, Guabiraba R, Garcia CC, Barcelos LS, Roffê E, Souza AL, Amaral FA, Cisalpino D, Cassali GD, Doni A, Bertini R, Teixeira MM. Am J Respir Cell Mol Biol. 2009 Apr;40(4):410-21. Epub 2008 Oct 3.
IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4. Kurowska-Stolarska M, Kewin P, Murphy G, Russo RC, Stolarski B, Garcia CC, Komai-Koma M, Pitman N, Li Y, Niedbala W, McKenzie AN, Teixeira MM, Liew FY, Xu D. J Immunol. 2008 Oct 1;181(7):4780-90.
Ticks produce highly selective chemokine binding proteins with antiinflammatory activity. Déruaz M, Frauenschuh A, Alessandri AL, Dias JM, Coelho FM, Russo RC, Ferreira BR, Graham GJ, Shaw JP, Wells TN, Teixeira MM, Power CA, Proudfoot AE. J Exp Med. 2008 Sep 1;205(9):2019-31. Epub 2008 Aug 4.
Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo. Pinho V, Russo RC, Amaral FA, de Sousa LP, Barsante MM, de Souza DG, Alves-Filho JC, Cara DC, Hayflick JS, Rommel C, Ruckle T, Rossi AG, Teixeira MM. J Immunol. 2007 Dec 1;179(11):7891-8.
LABORATORY OF EXPERIMENTAL ORAL PATHOLOGY
Albuquerque Taddei SR, Queiroz-Junior CM, Moura AP, Andrade I Jr, Garlet GP, Proudfoot AE, Teixeira MM, da Silva TA. The effect of CCL3 and CCR1 in bone remodeling induced by mechanical loading during orthodontic tooth movement in mice. Bone. 2012 Oct 8.
Madeira MF, Queiroz CM Jr, Costa GM, Santos PC, Silveira EM, Garlet GP, Cisalpino PS, Teixeira MM, Silva TA, Souza Dda G. MIF induces osteoclast differentiation and contributes to progression of periodontal disease in mice. Microbes Infect. 2012 Feb;14(2):198-206.
Queiroz-Junior CM, Madeira MF, Coelho FM, Costa VV, Bessoni RL, Sousa LF, Garlet GP, Souza Dda G, Teixeira MM, Silva TA. Experimental arthritis triggers periodontal disease in mice: involvement of TNF-α and the oral Microbiota. J Immunol. 2011 Oct 1;187(7):3821-30.
Andrade I Jr, Taddei SR, Garlet GP, Garlet TP, Teixeira AL, SilvaTA, Teixeira MM. CCR5 down-regulates osteoclast function in orthodontic tooth movement. J Dent Res. 2009 Nov;88(11):1037-41.
LABORATORY OF APOPTOSIS
Dengue-3 encephalitis promotes anxiety-like behavior in mice. Behav Brain Res. 2012 Apr 21;230(1):237-42. de Miranda AS, Rodrigues DH, Amaral DC, de Lima Campos RD, Cisalpino D, Vilela MC, Lacerda-Queiroz N, de Souza KP, Vago JP, Campos MA, Kroon EG, da Glória de Souza D, Teixeira MM, Teixeira AL, Rachid MA.
Intracerebral infection with dengue-3 virus induces meningoencephalitis and behavioral changes that precede lethality in mice. J Neuroinflammation. 2011 Mar 9;8:23. Amaral DC, Rachid MA, Vilela MC, Campos RD, Ferreira GP, Rodrigues DH, Lacerda-Queiroz N, Miranda AS, Costa VV, Campos MA, Kroon EG, Teixeira MM, Teixeira AL.
Anxiety-like behavior and proinflammatory cytokine levels in the brain of C57BL/6 mice infected with Plasmodium berghei (strain ANKA). Neurosci Lett. 2011 Mar 24;491(3):202-6. Epub 2011 Jan 21. de Miranda AS, Lacerda-Queiroz N, de Carvalho Vilela M, Rodrigues DH, Rachid MA, Quevedo J, Teixeira AL.
IMMUNOREGULATION OF INFECTIOUS DISEASES
ESPER, L ; ROMAN-CAMPOS, D. ; LARA, A. ; BRANT, F. ; Barroso A ; ARAUJO, R. R. S. ; VIEIRA, L. Q. ; Guatimosim, S ; Cruz, J S ; TANOWITZ, H. B. ; TEIXEIRA, M. M. ; MACHADO, F. S. . Role of SOCS2 in modulating heart damage and function in a murine model of acute chagas disease. In: XXXVI Congress of the Brazilian Society of Immunology, 2011, Foz do Iguaçu. XXXVI Congress of the Brazilian Society of Immunology, 2011. Download
MUKHERJEE, S. ; MACHADO, F. S. ; HUANG, H. ; OZ, H. S. ; JELICKS, L. A. ; PRADO, C. M. ; KOBA, W. ; ZHAO, D. ; FACTOR, S. ; COLLADO, J. E. ; WEISS, Download
L. M. ; TANOWITZ, H. B. ; ASHTON, A. W. . Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease. Plos One, v. 6, p. e16959, 2011. Download
MACHADO, F. S. ; MUKHERJEE, S. ; WEISS, L. M. ; TANOWITZ, H. B. ; ASHTON, A. W. . Bioactive Lipids in Trypanosoma cruzi Infection. Advances in Parasitology, v. 76, p. 1-31, 2011. Download
IMMUNOPHARMACOLOGY LAB
Amaral FA, Costa VV, Tavares LD, Sachs D, Coelho FM, Fagundes CT, Soriani FM, Silveira TN, Cunha LD, Zamboni DS, Quesniaux V, Peres RS, Cunha TM, Cunha FQ, Ryffel B, Souza DG, Teixeira MM. NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout. Arthritis Rheum. 2012 Feb;64(2):474-84.
Queiroz-Junior CM, Madeira MF, Coelho FM, Costa VV, Bessoni RL, Sousa LF, Garlet GP, Souza Dda G, Teixeira MM, Silva TA. Experimental arthritis triggers periodontal disease in mice: involvement of TNF-α and the oral Microbiota. J Immunol. 2011 Oct 1;187(7):3821-30.
Sachs D, Coelho FM, Costa VV, Lopes F, Pinho V, Amaral FA, Silva TA, Teixeira AL, Souza DG, Teixeira MM. Cooperative role of tumour necrosis factor-α, interleukin-1β and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice. Br J Pharmacol. 2011 Jan;162(1):72-83.
Coelho FM, Pinho V, Amaral FA, Sachs D, Costa VV, Rodrigues DH, Vieira AT, Silva TA, Souza DG, Bertini R, Teixeira AL, Teixeira MM. The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis Rheum. 2008 Aug;58(8):2329-37.
Amaral FA, Sachs D, Costa VV, Fagundes CT, Cisalpino D, Cunha TM, Ferreira SH, Cunha FQ, Silva TA, Nicoli JR, Vieira LQ, Souza DG, Teixeira MM.Commensal microbiota is fundamental for the development of inflammatory pain.Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2193-7.
TRANSLATIONAL PSYCHONEUROIMMUNOLOGY GROUP
Barbosa IG, Rocha NP, Huguet RB, Ferreira RA, Salgado JV, Carvalho LA, Pariante CM, Teixeira AL. Executive dysfunction in euthymic bipolar disorder patients and its association with plasma biomarkers. J Affect Disord. 2012; 137(1-3): 151-155
Calsavara AC, Rodrigues DH, Miranda AS, Costa PA, Lima CX, Vilela MC, Rachid MA, Teixeira AL. Late Anxiety-Like Behavior and Neuroinflammation in mice subjected to sublethal polymicrobial sepsis. Neurotox Res. 2012 [Epub ahead of print] PMID: 23224747.
Lacerda-Queiroz N, Rodrigues DH, Vilela MC, Rachid MA, Soriani FM, Sousa LP, Campos RD, Quesniaux VF, Teixeira MM, Teixeira AL. Platelet-activating factor receptor is essential for the development of experimental cerebral malaria. Am J Pathol. 2012; 180(1):246-255.
Rocha NP, Teixeira AL, Coelho FM, Caramelli P, Guimarães HC, Barbosa IG, da Silva TA, Mukhamedyarov MA, Zefirov AL, Rizvanov AA, Kiyasov AP, Vieira LB, Janka Z, Palotás A, Reis HJ. Peripheral blood mono-nuclear cells derived from Alzheimer's disease patients show elevated baseline levels of secreted cytokines but resist stimulation with β-amyloid peptide. Mol Cell Neurosci. 2012;49(1):77-84.
Teixeira AL, Diniz BS, Campos AC, Miranda AS, Rocha NP, Talib LL, Gattaz WF, Forlenza OV. Decreased levels of circulating adiponectin in mild cognitive impairment and Alzheimer's disease. Neuromolecular Med. 2012 [Epub ahead of print] PMID:23055000.
VIANA Heloisa Reiners, SOARES, Cristina B M, da Silveira, Kátia D, ELMIRO Gustavo Siqueira, MENDES Philipe Melgaço, TAVARES, Marcelo Souza, TEIXEIRA, Mauro Martins, Miranda, Débora Marques, Simoes e Silva, Ana Cristina. Cytokines in chronic kidney disease: potential link of MCP-1 and dyslipidemia in glomerular diseases. Pediatric Nephrology (Berlin, West) , 2012, DOI: 10.1007/s00467-012-2363-x.
Santos, Augusto C. S., Lima, Eleonora M., Penido, Maria Goretti M. G., Silveira, Katia D., TEIXEIRA, MAURO M., Oliveira, Eduardo A., Simões e Silva, Ana Cristina. Plasma and urinary levels of cytokines in patients with idiopathic hypercalciuria. Pediatric Nephrology (Berlin, West). , p.941-948, 2012.
Simões e Silva, Ana Cristina, Flynn, Joseph T. The renin-angiotensin-aldosterone system in 2011: role in hypertension and chronic kidney disease. Pediatric Nephrology (Berlin, West). , v.27, p.1835-1845, 2012.
Pereira, André Barreto, Teixeira, Antônio Lúcio, Rezende, Nilton Alves, PEREIRA, Regina Maria, Miranda, Débora Marques, Oliveira, Eduardo Araujo, TEIXEIRA, MAURO M., Simões e Silva, Ana Cristina. Urinary chemokines and anti-inflammatory molecules in renal transplanted patients as potential biomarkers of graft function: a prospective study. International Urology and Nephrology. , v.44, p. 1539-1548, 2012.
Vasconcelos, Mariana A., Bouzada, Maria Candida F., Silveira, Katia D., Moura, Leticia R., Santos, Fabiana F., Oliveira, Juliana M., Carvalho, Flavia F., TEIXEIRA, MAURO M., Simões e Silva, Ana Cristina, Oliveira, Eduardo A. Urinary levels of TGF β-1 and of cytokines in patients with prenatally detected nephrouropathies. Pediatric Nephrology (Berlin, West). , v.26, p.739-747, 2011.
Laboratory of Pulmonary Immunology and Mechanics
TEIXEIRA, M. M. ; GARCIA, C. C. ; RUSSO, R. C. ; MACHADO, A. M. V. ; GAZZINELLI, R. T. . Uso de antagonistas do Receptor do Fator de Ativação Plaquetária para o tratamento de infeccoes causadas pelo virus Influenza. 2007, Brasil. Patente: Privilégio de Inovação. Número do registro: PI220705505518, data de depósito: 08/11/2007, título: ‘"Uso de antagonistas do Receptor do Fator de Ativação Plaquetária para o tratamento de infeccoes causadas pelo virus Influenza” . Instituição(ões) financiadora(s): Universidade Federal de Minas Gerais.
